Radiological findings of complications after lung transplantation. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections, and malignancy. Post-surgical dysfunction could be depicted on computed tomography CTsuch as bronchial anastomosis dehiscence, bronchial stenosis and bronchomalacia, pulmonary artery stenosis, and size mismatch
Describe the evidence on which you base your management of patients with neutropenic fever. Write short notes on: Describe the principles by which the safety of blood components red cells, platelets and fresh frozen plasma is achieved by a blood transfusion service.
Illustrate your answer with a list of the specific measures which are currently employed. What other measures are available that might affect blood component safety and what impact might these have if introduced within a national transfusion service?
Discuss the haematological abnormalities found in association with HIV human immunodeficiency virus infection and its treatment. You are asked to see a thirty-eight year old woman who is currently twenty-five weeks pregnant.
She gives a history that her maternal grandfather was a haemophiliac and died many years before. She has no details of this history. Discuss how you would manage this. Write short notes Post transplant lymphoproliferative disease essay the following: Describe the haematological diseases which may be associated with the hyperviscosity syndrome and their clinical management.
Describe the classification of myelodysplastic syndromes MDS and discuss how you would clinically treat patients suffering from different types of MDS. Describe the patho physiology of vaso-occlusive crises in Sickle Cell disease and relate this to the clinical management of vaso-occlusive crises.
Describe the laboratory tests which are used to monitor anticoagulation therapy and indicate how you would use them in the management of patients.
Write short notes on both the methods used for the measurement of the following and also the interpretation of the results: Describe how you would diagnose and manage this condition and discuss the strategies for preventing TRALI.
Discuss the pathogenesis, diagnosis and management of disseminated intravascular coagulation. Describe how you would investigate and clinically manage a 70 year old man with severe autoimmune haemolytic anaemia.
Discuss the pathogenesis, investigation and management of amyloidosis. How would you investigate and clinically manage a 40 year old man with Hairy Cell Leukaemia? Discuss the evidence base for your decisions on the diagnosis and management of autoimmune thrombocytopenic purpura. Discuss the relationship between the genetic defect s and the clinical features of: Describe the principles and practical measures which are important in the monitoring of warfarin treatment.
Discuss the ways in which the haematology laboratory may be involved in a near patient testing service for control of oral anticoagulation therapy. Discuss the role of hydroxyurea in the treatment of haematological disorders. Discuss how these may be prevented. Discuss the use of recombinant erythropoietin as a therapeutic agent in patients with haematological disorders.
Describe the pathogenesis, diagnosis and management of acute promyelocytic leukaemia FAB M3. Discuss the pathogenesis, diagnosis and management of sideroblastic anaemias. Discuss the pathophysiological basis and approach to management of thrombosis associated with: Discuss the investigation, differential diagnosis and management of a middle-aged man found to have an haematocrit of 0.
Using evidence based information describe your approach to the diagnosis and management of multiple myeloma.Post-transplant lymphoproliferative disease (PTLD) comprises a wide spectrum of lymphoproliferative conditions following solid organ or haematopoietic stem cell transplantation (HSCT) and may occur in up to 10% of adults post transplant.
Successful treatment of systemic and central nervous system post-transplant lymphoproliferative disorder without the use of high-dose methotrexate or radiation. Pediatric Blood & Cancer, . Abstract. Abstract: The development of post-transplant lymphoproliferative disorders (PTLD) is a well-recognized complication of solid organ transplantation in patients receiving immunosuppressive therapy.
The literature on PTLD in live renal allograft recipients is scarce and most of the data pertains to PTLD in cadaveric transplants.
Among these cancers, Burkitt’s lymphoma, leiomyosarcomas and post-transplant lymphoproliferative diseases have been noted to demonstrate an increased frequency in patients who have immunodeficiency; hence, suggesting immunosurveillance role in the malignant transformation suppression (Moore & Chang, ).
post-transplant lymphoproliferative disease PTLD immunosuppression Epstein Barr Virus EBV transplantation Declaration of Interests The BSH paid the expenses incurred during . Aibin Zhang, Min Zhang, Yan Shen, Weilin Wang and Shusen Zheng, Hepatitis B virus reactivation is a risk factor for development of post‐transplant lymphoproliferative disease after liver transplantation, Clinical Transplantation, 23, 5, (), ().